Prometeo Gallery was born on the initiative of Ida Pisani, after a long history as a cultural association that evolved in 2005 into a gallery based in Milan and Lucca. It has always distinguished itself as a catalyst for the social and political demands of multimedia visual artists.
The project opened with “Perra” by the Guatemalan artist Regina José Galindo (b. 1974), who won the Golden Lion at the Venice Biennale as best artist under 35 in 2005. This award was previously given in 2001 to Aníbal López (A-1 53167) (b. 1964): another Guatemalan artist with whom the gallery began a relationship, interrupted by his untimely death at the age of 50 years old. Galindo's work "Tierra" (2013) became part of the MoMA’s permanent collection in 2021, as the third work of the artist acquired by the museum. In the same year, she was awarded with the "Robert Rauschenberg Award”.
The first Italian exhibition by the Spanish master Santiago Sierra (b. 1966) "Trabajos Italianos”, dates back to 2007. Among the most recent works, Sierra is behind the muddy Balenciaga runway at Paris Fashion Week 2022, taking inspiration from the work "House in Mud" realized in 2005 on the ground floor of the Kestnergesellschaft, Hannover.
In 2017, four artists represented by Prometeo Gallery were invited to the 14th edition of Documenta: Stefano Tsivopoulos (b. 1973), Regina José Galindo, Mary Zygouri (b. 1973), Hiwa K (b. 1975). Among the artists invited to show at the Venice Biennale over the years: Ivan Moudov (b. 1975), Giuseppe Stampone (b. 1974), Regina José Galindo, Mary Zygouri, Stefano Tsivopoulos, Hiwa K.
In 2019, the gallery has started representing the work of the Kurdish artist Zehra Doğan (b. 1989), who was included in Art Review's "Power 100" in 2020 and 2021. In 2022, Prometeo Gallery has started representing the work of the Italian-Senegalese visual artist Binta Diaw (b. 1995) with her first solo show at the gallery entitled “La plage noire”.